Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles.

@article{Shin2011TimeorientedED,
  title={Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles.},
  author={Sangmun Shin and Du Hyung Choi and Nguyen Khoa Viet Truong and Nam Ah Kim and Kyung Rok Chu and Seong Hoon Jeong},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={407 1-2},
  pages={
          53-62
        }
}
A new experimental design methodology was developed by integrating the response surface methodology and the time series modeling. The major purposes were to identify significant factors in determining swelling and release rate from matrix tablets and their relative factor levels for optimizing the experimental responses. Properties of tablet swelling and drug release were assessed with ten factors and two default factors, a hydrophilic model drug (terazosin) and magnesium stearate, and compared… CONTINUE READING
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