Time of replication of yeast centromeres and telomeres.

@article{McCarroll1988TimeOR,
  title={Time of replication of yeast centromeres and telomeres.},
  author={Robert M. McCarroll and Walton L. Fangman},
  journal={Cell},
  year={1988},
  volume={54 4},
  pages={505-13}
}
The time of replication of centromeres and telomeres of the yeast S. cerevisiae was determined by performing Meselson-Stahl experiments with synchronized cells. The nine centromeres examined become hybrid in density early in S phase, eliminating the possibility that a delay in the replication of centromeres until mitosis is responsible for sister chromatid adherence and proper chromosome segregation at anaphase. The conserved sequence element Y', present at most telomeres, replicates late in S… CONTINUE READING

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