Time-of-day modulation of homeostatic and allostatic sleep responses to chronic sleep restriction in rats.

@article{Deurveilher2012TimeofdayMO,
  title={Time-of-day modulation of homeostatic and allostatic sleep responses to chronic sleep restriction in rats.},
  author={Sam{\"u}el Deurveilher and Benjamin Rusak and Kazunori Semba},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2012},
  volume={302 12},
  pages={R1411-25}
}
To study sleep responses to chronic sleep restriction (CSR) and time-of-day influences on these responses, we developed a rat model of CSR that takes into account the polyphasic sleep patterns in rats. Adult male rats underwent cycles of 3 h of sleep deprivation (SD) and 1 h of sleep opportunity (SO) continuously for 4 days, beginning at the onset of the 12-h light phase ("3/1" protocol). Electroencephalogram (EEG) and electromyogram (EMG) recordings were made before, during, and after CSR… CONTINUE READING