Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.

@article{Eyre2014TimeNT,
  title={Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.},
  author={Toby A Eyre and Graham Peter Collins and Anthony H. Goldstone and Kate Cwynarski},
  journal={British journal of haematology},
  year={2014},
  volume={166 3},
  pages={336-51}
}
Since the discovery of rapamycin in Easter Island soil in 1975, more has been learnt about the relevance and importance of the mammalian target of rapamycin (mTOR) pathway in cell signalling, proliferation and ultimately tumourigenesis. Rapamycin targets the mTORC1 complex alone. Despite initial excitement, rapamycin and its analogues, everolimus and temsirolimus, have displayed limited efficacy in the treatment of lymphoid malignancies. This review highlights the important and well-described… CONTINUE READING
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