Time-lapse observation of cell alignment on nanogrooved patterns.

  title={Time-lapse observation of cell alignment on nanogrooved patterns.},
  author={Satoshi Fujita and Masahiro Ohshima and Hiroo Iwata},
  journal={Journal of the Royal Society, Interface},
  volume={6 Suppl 3},
Cells elongate on a surface with nanogrooved (NG) patterns and align along that pattern. Although various models have been proposed for how this occurs, much remains to be clarified. Studies with fixed cells do not lend themselves to answering some of these open questions. In this study, the dynamic behaviours of living mesenchymal stem cells on an NG substrate with a 200 nm groove depth, an 870 nm ridge width and a 670 nm groove width were observed using time-lapse microscopes. We found that… CONTINUE READING

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