Time for revival of estrogens in the treatment of advanced prostatic carcinoma? Pharmacokinetics, and endocrine and clinical effects, of a parenteral estrogen regimen
@article{Henriksson1999TimeFR, title={Time for revival of estrogens in the treatment of advanced prostatic carcinoma? Pharmacokinetics, and endocrine and clinical effects, of a parenteral estrogen regimen}, author={Peter Henriksson and Kjell Carlstr{\"o}m and {\AA}ke Pousette and P O Gunnarsson and Carl J. Johansson and Birgitta Eriksson and Ann Kristin Altersg{\aa}rd‐Brorsson and {\"O}rjan Nordle and Reinhard Stege}, journal={The Prostate}, year={1999}, volume={40} }
The present pilot study tested the clinical performance of a new pharmacokinetically guided dosing regimen of parenteral estrogen in patients with advanced prostatic carcinoma. The aim was to accelerate endocrine effects and to avoid cardiovascular side effects.
27 Citations
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Parenteral estrogen therapy has the advantage of giving protection against the effects of andropause, which are induced by conventional androgen suppression and include osteoporotic fracture, hot flashes, asthenia and cognitive dysfunction.
androgen deprivation therapy for prostate cancer - the potential of parenteral estrogen
- Medicine, Biology
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Parenteral estrogen therapy is protection against the effects of the andropause (cf female menopause), which with conventional androgen suppression causes significant morbidity including osteoporotic fracture, hot flushes, lethargy and cognitive dysfunction.
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- Medicine
- 2006
The great majority of evidence was concerned with i.m. PEP, but was largely of poor quality or was poorly reported, and the largest and highest quality trials included in the review do not provide long-term survival data.
The evolving role of estrogen therapy in prostate cancer.
- Medicine, BiologyClinical prostate cancer
- 2002
There remain many unanswered questions about the role of estrogen therapy in prostate cancer, including differences between specific drugs, optimal dose, timing, and patient selection.
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