Time for revival of estrogens in the treatment of advanced prostatic carcinoma? Pharmacokinetics, and endocrine and clinical effects, of a parenteral estrogen regimen

@article{Henriksson1999TimeFR,
  title={Time for revival of estrogens in the treatment of advanced prostatic carcinoma? Pharmacokinetics, and endocrine and clinical effects, of a parenteral estrogen regimen},
  author={Peter Henriksson and Kjell Carlstr{\"o}m and {\AA}ke Pousette and P O Gunnarsson and Carl J. Johansson and Birgitta Eriksson and Ann Kristin Altersg{\aa}rd‐Brorsson and {\"O}rjan Nordle and Reinhard Stege},
  journal={The Prostate},
  year={1999},
  volume={40}
}
The present pilot study tested the clinical performance of a new pharmacokinetically guided dosing regimen of parenteral estrogen in patients with advanced prostatic carcinoma. The aim was to accelerate endocrine effects and to avoid cardiovascular side effects. 

Pharmacodynamic model of testosterone suppression after intramuscular depot estrogen therapy in prostate cancer

A model is described predicting the effect on testosterone flux achieved with this estrogen drug, PEP, which has been in clinical use for several years in combination therapy and pharmacokinetically and clinically as a single treatment.

Phase II study of transdermal estradiol in androgen‐independent prostate carcinoma

The authors tested the safety and efficacy of transdermal estradiol (TDE), as well as the effect of therapy on hot flashes, sex hormones, the procoagulant cascade, and bone turnover in patients with AIPC.

Diethylstilboestrol for the treatment of prostate cancer: past, present and future

The most relevant clinical studies using DES in castration-refractory prostate cancer (CRPC) were identified from the literature and the efficacy of oestrogen therapy in CRPC is highlighted.

Parenteral estrogens for prostate cancer: can a new route of administration overcome old toxicities?

The data for parenteral estrogen use in prostate cancer, the antineoplastic mechanisms of action of estrogen in prostate Cancer, the potential advantages of parenTERal estrogen compared with conventional ADT, and the remaining barriers in the use of p Karenteralosterone in prostatecancer are reviewed.

Parenteral Estrogen versus Combined Androgen Deprivation in the Treatment of Metastatic Prostatic Cancer - Scandinavian Prostatic Cancer Group (SPCG) Study No. 5

High-dose polyestradiol phosphate (PEP) has an equal anticancer efficacy to CAD and does not increase cardiovascular mortality, and is considerably cheaper than CAD.

Therapy Insight: parenteral estrogen treatment for prostate cancer—a new dawn for an old therapy

Parenteral estrogen therapy has the advantage of giving protection against the effects of andropause, which are induced by conventional androgen suppression and include osteoporotic fracture, hot flashes, asthenia and cognitive dysfunction.

androgen deprivation therapy for prostate cancer - the potential of parenteral estrogen

Parenteral estrogen therapy is protection against the effects of the andropause (cf female menopause), which with conventional androgen suppression causes significant morbidity including osteoporotic fracture, hot flushes, lethargy and cognitive dysfunction.

Parenteral oestrogens for prostate cancer: a systematic review of clinical effectiveness and dose response

The great majority of evidence was concerned with i.m. PEP, but was largely of poor quality or was poorly reported, and the largest and highest quality trials included in the review do not provide long-term survival data.

The evolving role of estrogen therapy in prostate cancer.

  • W. Oh
  • Medicine, Biology
    Clinical prostate cancer
  • 2002
There remain many unanswered questions about the role of estrogen therapy in prostate cancer, including differences between specific drugs, optimal dose, timing, and patient selection.

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