Time for revival of estrogens in the treatment of advanced prostatic carcinoma? Pharmacokinetics, and endocrine and clinical effects, of a parenteral estrogen regimen

@article{Henriksson1999TimeFR,
  title={Time for revival of estrogens in the treatment of advanced prostatic carcinoma? Pharmacokinetics, and endocrine and clinical effects, of a parenteral estrogen regimen},
  author={Peter Henriksson and Kjell Carlstr{\"o}m and {\AA}ke Pousette and P O Gunnarsson and Carl J. Johansson and Birgitta Eriksson and Ann Kristin Altersg{\aa}rd‐Brorsson and {\"O}rjan Nordle and Reinhard Stege},
  journal={The Prostate},
  year={1999},
  volume={40}
}
The present pilot study tested the clinical performance of a new pharmacokinetically guided dosing regimen of parenteral estrogen in patients with advanced prostatic carcinoma. The aim was to accelerate endocrine effects and to avoid cardiovascular side effects. 
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27 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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27 Citations

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The great majority of evidence was concerned with i.m. PEP, but was largely of poor quality or was poorly reported, and the largest and highest quality trials included in the review do not provide long-term survival data.

The evolving role of estrogen therapy in prostate cancer.

  • W. Oh
  • Medicine, Biology
    Clinical prostate cancer
  • 2002
There remain many unanswered questions about the role of estrogen therapy in prostate cancer, including differences between specific drugs, optimal dose, timing, and patient selection.

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