Time for changing coagulation management in trauma-related massive bleeding.

  title={Time for changing coagulation management in trauma-related massive bleeding.},
  author={Dietmar R. Fries and Petra Innerhofer and Wolfgang Schobersberger},
  journal={Current opinion in anaesthesiology},
  volume={22 2},
PURPOSE OF REVIEW New insights into the pathophysiology of trauma-induced coagulopathy, the increasing availability of point-of-care devices and awareness of side effects of intravenous fluids and traditional fresh frozen plasma therapy has encouraged new concepts for managing massive blood loss. RECENT FINDINGS Trauma-induced coagulopathy primarily results from blood loss, hypovolemia-induced activation of the protein C system and consequent increase of the fibrinolytic potential, whereas… CONTINUE READING
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