Time for changing coagulation management in trauma-related massive bleeding

  title={Time for changing coagulation management in trauma-related massive bleeding},
  author={D. Fries and P. Innerhofer and W. Schobersberger},
  journal={Current Opinion in Anaesthesiology},
  • D. Fries, P. Innerhofer, W. Schobersberger
  • Published 2009
  • Medicine
  • Current Opinion in Anaesthesiology
  • Purpose of review New insights into the pathophysiology of trauma-induced coagulopathy, the increasing availability of point-of-care devices and awareness of side effects of intravenous fluids and traditional fresh frozen plasma therapy has encouraged new concepts for managing massive blood loss. Recent findings Trauma-induced coagulopathy primarily results from blood loss, hypovolemia-induced activation of the protein C system and consequent increase of the fibrinolytic potential, whereas… CONTINUE READING
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