Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach.

@article{Hunter2010TimeFA,
  title={Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach.},
  author={Sally Hunter and Robert P Friedland and Carol Brayne},
  journal={CNS neuroscience & therapeutics},
  year={2010},
  volume={16 4},
  pages={254-62}
}
The amyloid cascade hypothesis, based on the genetic data from early onset, familial forms of the disease, has been the dominant model for many years and involves over production and deposition of the beta amyloid protein as causal in the disease process. However, it does not apply very well to the more common, later onset, sporadic form of the disease, where a wider range of factors appear to be involved in disease progression. Over recent years, data illustrating reciprocal interactions… CONTINUE READING