Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone.

@article{Zhang2008TimedependentTP,
  title={Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone.},
  author={Xiaowei Zhang and Markus Hecker and June-Woo Park and Amber R. Tompsett and Paul D Jones and John Newsted and Doris Wai-Ting Au and Richard Yuen Chong Kong and Rudolf Shiu Sun Wu and John P. Giesy},
  journal={Environmental toxicology and chemistry},
  year={2008},
  volume={27 12},
  pages={
          2504-11
        }
}
Both the anabolic androgen 17beta-trenbolone (TRB) and the aromatase inhibitor fadrozole (FAD) can cause decreased plasma concentrations of estrogen (E2) and reduce fecundity of fish. However, the underlying mechanisms and the molecular pathways involved are largely unknown. The present study was designed to assess time-dependent effects of FAD and TRB on the transcriptional responses of the hypothalamic-pituitary-gonadal (HPG) axis of Japanese medaka (Oryzias latipes). Fourteen-week-old… 
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