Time-dependent reversal of dentate LTP by 5 Hz stimulation.

  title={Time-dependent reversal of dentate LTP by 5 Hz stimulation.},
  author={Stephen J Martin},
  volume={9 17},
Field potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was… CONTINUE READING


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