Time-dependent protective effects of calcium channel blockers on anoxia- and hypoxia-induced proximal tubule injury.

@article{Almeida1992TimedependentPE,
  title={Time-dependent protective effects of calcium channel blockers on anoxia- and hypoxia-induced proximal tubule injury.},
  author={Andr{\'e} L R Almeida and Derek Bunnachak and Michel Burnier and Jack F. M. Wetzels and Thomas J. Burke and Robert Schrier},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={260 2},
  pages={526-32}
}
The effects of anoxia or hypoxia on Ca++ uptake and lactic dehydrogenase (LDH) release were examined in freshly isolated rat proximal tubules (rPT). Both Ca++ uptake and LDH release were increased above control after only 10 min of either anoxia or hypoxia in rPT. The increase in Ca++ uptake was through voltage-sensitive, slow Ca++ channels, because pretreatment with chemically dissimilar calcium channel blockers (CCB), either verapamil or flunarizine, prevented the increased Ca++ uptake and… CONTINUE READING
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