Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer.

@article{Ibrahim2012TimedependentPO,
  title={Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer.},
  author={Toni Ibrahim and Antonello Di Paolo and Federica Amatori and Laura Mercatali and Elena Ravaioli and Emanuela Flamini and Emanuele Sacanna and Mario del Tacca and Romano Danesi and Dino Amadori},
  journal={Journal of clinical pharmacology},
  year={2012},
  volume={52 3},
  pages={361-9}
}
The authors evaluated the influence of 5-fluorouracil (5-FU) on treatment tolerability in 81 colorectal cancer patients given adjuvant 5-FU intravenously plus folinic acid for 6 cycles. The pharmacokinetics of 5-FU and its inactive metabolite 5-fluoro-5,6-dihydrouracil (5-FDHU) were measured on days 1 and 5 of the first chemotherapy cycle, 5 and 45 minutes… CONTINUE READING