Time-dependent oxidative stress caused by benznidazole.

  title={Time-dependent oxidative stress caused by benznidazole.},
  author={Andreza Fabro de Bem and Claudriana Locatelli and Rozangela Curi Pedrosa and Reginaldo Geremias and Danilo Wilhelm Filho},
  journal={Redox report : communications in free radical research},
  volume={6 4},
Benznidazole (BZN) is a nitroimidazole derivative which has a notable trypanocide activity, and it is the only drug used in Brazil and Argentina for the treatment of Chagas' disease. The drug in current use is thought to act, at least in part, by inducing oxidative stress within the parasite. Imidazolic compounds are involved in the production of reactive oxygen species (ROS). In order to evaluate the effect of BZN on ROS production and on the antioxidant status of the host, male rats were… CONTINUE READING