Time-dependent formation of 8-oxo-deoxyguanosine in the lungs of mice exposed to cigarette smoke.


Active and passive smoking are major risk factors for lung cancer. Pro-oxidants in tobacco smoke have been implicated in smoking-associated disease development due to their potential role in inducing oxidative stress. Previous studies have failed to associate increased levels of oxidative damage to DNA with the formation of the potentially mutagenic lesion… (More)


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