Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach

@article{Bamba2000TimedependentEO,
  title={Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach},
  author={Masamichi Bamba and Hiroyuki Sugihara and Ryoji Kushima and Katsuji Okada and Shizuki Tsukashita and Michiko Horinouchi and Takanori Hattori},
  journal={Virchows Archiv},
  year={2000},
  volume={438},
  pages={49-56}
}
Signet ring cell carcinomas of the stomach are thought to arise from the proper gastric mucosa without intestinal metaplasia. It was recently reported that intestinal phenotypes appear along with tumor progression. In this study, we performed several experiments to reconsider the significance of this intestinalization in the growth of signet ring cell carcinoma. We applied mucin histochemistry with monoclonal antibodies MUC2 (Ccp58) and M1 (45M1), and paradoxical concanavalin A staining for… CONTINUE READING
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