Time-dependent effects of aspirin on blood pressure and morning platelet reactivity: a randomized cross-over trial.

@article{Bonten2015TimedependentEO,
  title={Time-dependent effects of aspirin on blood pressure and morning platelet reactivity: a randomized cross-over trial.},
  author={Tobias N. Bonten and Jaapjan D Snoep and Willem J. J. Assendelft and Jaap J Zwaginga and Jeroen C J Eikenboom and Menno V. Huisman and Frits R Rosendaal and Johanna G van der Bom},
  journal={Hypertension},
  year={2015},
  volume={65 4},
  pages={743-50}
}
Aspirin is used for cardiovascular disease (CVD) prevention by millions of patients on a daily basis. Previous studies suggested that aspirin intake at bedtime reduces blood pressure compared with intake on awakening. This has never been studied in patients with CVD. Moreover, platelet reactivity and CVD incidence is highest during morning hours. Bedtime aspirin intake may attenuate morning platelet reactivity. This clinical trial examined the effect of bedtime aspirin intake compared with… CONTINUE READING

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