Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudate-putamen.

@article{Corchero1999TimedependentDO,
  title={Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudate-putamen.},
  author={Javier Corchero and J. J. Romero and Fernando Berrendero and Javier J. Fernandez-Ruiz and Jos{\'e} Antonio Vera Ramos and Jos{\'e} Antonio Guti{\'e}rrez Fuentes and Jorge Manzanares},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={67 1},
  pages={148-57}
}
The purpose of the present study was to examine the time-related effects of repeated administration of Delta9-tetrahydrocannabinol during 1, 3, 7 and 14 days on cannabinoid and mu-opioid receptor agonist-stimulated [35S]GTPgammaS binding, and CB1 cannabinoid receptor and proenkephalin gene expression in the caudate-putamen. Repeated administration with Delta9-tetrahydrocannabinol produced a time-related reduction in cannabinoid receptor synthesis and activation of signal transduction mechanisms… CONTINUE READING

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