Time-dependent coronary blood flow distribution in left ventricular wall.

  title={Time-dependent coronary blood flow distribution in left ventricular wall.},
  author={Rafael Beyar and Samuel Sideman},
  journal={The American journal of physiology},
  volume={252 2 Pt 2},
  • R. Beyar, S. Sideman
  • Published 1 February 1987
  • Engineering, Medicine, Biology
  • The American journal of physiology
A mathematical model of the coronary circulation in the left ventricular (LV) wall, which describes the time-dependent local blood perfusion throughout the myocardium and the coronary flow in the epicardial vessels, is presented. The myocardial perfusion is essentially controlled by the intramyocardial resistance and the coronary pressure driving force, whereas the epicardial arterial flow is dominated by the epicardial and intramyocardial arterial capacitance and the local transmural pressure… 
A model of the coronary epicardial tree and intramyocardial circulation in normal and ischemic hearts
A dynamic electrical analog RC model describing the coronary circulation was developed to relate the epicardial flow to the corresponding regional perfusion and has the ability to autoregulate in response to increased flow demand or severe stenosis.
Model of the coronary circulation based on pressure dependence of coronary resistance and compliance
It is concluded that interpretation of transients in coronary flow and/or pressure by models containing fixed resistance and capacitance may seriously underestimate intramyocardial capacitative effects and characteristic time constants for pressure-induced resistance changes.
Analysis of flow in coronary epicardial arterial tree and intramyocardial circulation
The model presents a quantitative tool that describes the dynamic pattern of coronary flow in relationship to muscular and extravascular parameters, and Interestingly, the transmurally average microcirculatory flow is continuous, with very small change throughout the cardiac cycle, and is practically insensitive to changes in the model parameters.
Effects of myocardial contraction on coronary blood flow: An integrated model
The results indicate a domiant effect of the myocardial contractile state on coronary flow and a dissocation between coronary compression and LV cavity pressure (LVP) when the pressure is controlled by load changes.
On the Mechanism of Transmural Myocardial Compression and Perfusion
It is shown that when the left ventricle (LV) operates under conditions involving high shortening, such as decreased afterload and increased contractility, a considerable difference between the IMP at the subendocardium and the LV cavity pressure can develop.
Phasic Waveforms of Coronary Arterial and Venous Blood Flow Predicted by a Numerical Model of the Coronary Circulation
The model accurately predicted the nearly 180° phase shift between coronary inflow and outflow and predicted phasic waveforms of coronary arterial and venous blood flow were comparable to those measured experimentally in the LAD coronary artery and great cardiac vein of dogs.
Dynamic interaction between myocardial contraction and coronary flow.
A new model is proposed, linking a muscle collagen fibrous model to a physiologically based coronary model, and accounting for transport of fluids across the capillaries and lymphatic flow between the interstitial space and the venous system, which predicts a wide range of experimentally observed phenomena associated with coronary compression.
Myocardial mechanics and coronary flow dynamics.
Coronary compression is shown to be affected by fluid transport and the bi-directional coupling of coronary hemodynamics and IMP dynamics and is presented here based on the dynamics of the coronary inflow under constant perfusion conditions.