Time-dependent closed form solutions for fully competitive enzyme reactions.

  title={Time-dependent closed form solutions for fully competitive enzyme reactions.},
  author={Santiago Schnell and C. Mendoza},
  journal={Bulletin of mathematical biology},
  volume={62 2},
An analytic formalism developed earlier to describe the time evolution of the basic enzyme reaction is extended to fully competitive systems. Time-dependent closed form solutions are derived for the three nominal cases of competition: even, slow and fast inhibitors, allowing for the first time the complete characterization of the reactions. In agreement with previous work, the time-independent Michaelis-Menten approach is shown to be inaccurate when a fast inhibitor is present. The validity of… CONTINUE READING

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