Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade.

@article{OConnor2004TimedependentCI,
  title={Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade.},
  author={Kerry Ann O'Connor and Linda J. Porrino and Huw M. L. Davies and Steven R. Childers},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={313 2},
  pages={
          510-7
        }
}
The potent tropane analog, WF-23 [2beta-propanoyl-3beta-(2-naphthyl) tropane], blocks dopamine, serotonin, and norepinephrine transporters with high affinity in vitro and blocks transporters for at least 2 days following a single in vivo administration. Previous studies demonstrated desensitization of monoamine receptor-coupled G-proteins in brain following chronic treatment of rats with WF-23. The current study sought to determine the time course of this desensitization and the behavioral… CONTINUE READING

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