Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.

@article{Hanck1992TimedependentCI,
  title={Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.},
  author={Dorothy A. Hanck and Michael F. Sheets},
  journal={The American journal of physiology},
  year={1992},
  volume={262 4 Pt 2},
  pages={H1197-207}
}
The spontaneous hyperpolarizing shift in Na+ channel kinetics that occurs during a series of voltage-clamp recordings was characterized in single canine cardiac Purkinje cells at 10-13.5 degrees C. The change in the half-point of voltage-dependent availability, in the half-point of peak conductance, in the voltage dependence of deactivation and time to peak Na+ channel current (INa), and in the time constants of INa decay in response to step depolarizations were examined. The half points of… CONTINUE READING