Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia

@article{Lee2012TimedependentCI,
  title={Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia},
  author={Euhan J. Lee and Laura C Alonso and Darko Stefanovski and Hilary C. Strollo and Lia C. Romano and Baobo Zou and Srikanth Singamsetty and Keith A. Yester and Kenneth R. McGaffin and Adolfo Garc{\'i}a-Oca{\~n}a and Christopher P. O’Donnell},
  journal={European Journal of Applied Physiology},
  year={2012},
  volume={113},
  pages={467-478}
}
Hypoxia manifests in many forms including the short repetitive intermittent hypoxia (IH) of sleep apnoea and the continuous hypoxia (CH) of altitude, both of which may impact metabolic function. Based on our own previous studies and the available literature, we hypothesized that whereas acute exposure to IH and CH would lead to comparable metabolic dysfunction, with longer-term exposure, metabolism would normalize to a greater extent with CH than IH. Studies were conducted in lean C57BL/6J mice… CONTINUE READING
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