Time-dependent and lesion-dependent HMGB1-selective localization in brains of patients with cerebrovascular diseases.

@article{Umahara2018TimedependentAL,
  title={Time-dependent and lesion-dependent HMGB1-selective localization in brains of patients with cerebrovascular diseases.},
  author={Takahiko Umahara and Toshiki Uchihara and Katsuiku Hirokawa and Kentaro Hirao and Soichiro Shimizu and Takao Hashimoto and Hiroo Terasi and Haruo Hanyu},
  journal={Histology and histopathology},
  year={2018},
  volume={33 2},
  pages={
          215-222
        }
}
High mobility group box 1 protein (HMGB1) has multiple functions, including the maintenance of nucleosomes and the regulation of gene transcription. HMGB1 is released from activated macrophages, resulting in the induction of inflammatory cytokines. Recently, much research about the role of HMGB1 in cerebrovascular disease (CVD) has been reported. In an animal model, HMGB1 neutralization ameliorates brain infarction, there is an early release of HMGB1 from neurons, and HMGB1 antibody attenuates… CONTINUE READING
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