Time-dependent activation of ERK1/2 in nerve terminals of the dentin-pulp complex following bradykinin treatment.

@article{Korkmaz2008TimedependentAO,
  title={Time-dependent activation of ERK1/2 in nerve terminals of the dentin-pulp complex following bradykinin treatment.},
  author={Y{\"u}ksel Korkmaz and Wilhelm Bloch and Kurt Schneider and Stefan Zimmer and Klaus Addicks and Wolfgang H. M. Raab},
  journal={Journal of dental research},
  year={2008},
  volume={87 12},
  pages={1149-54}
}
The extracellular signal-regulated kinases 1 and 2 (ERK1/2) have been implicated in the inflammation-dependent sensitization of nociceptors, and the inflammatory mediator bradykinin (BK) led to a reduced threshold in the nociceptor terminals, activating intracellular signaling by phosphorylating receptors and ion channels. The effects of BK on the non… CONTINUE READING