Time-dependence of lung injury in mice acutely exposed to cylindrospermopsin.

  title={Time-dependence of lung injury in mice acutely exposed to cylindrospermopsin.},
  author={Vin{\'i}cius Rosa Oliveira and Giovanna Marcella Cavalcante Carvalho and Mariana Barcellos {\'A}vila and Raquel Moraes Soares and Sandra Maria Feliciano de Oliveira e Azevedo and Thiago Rogel Santos Ferreira and Samuel Santos Valenca and D{\'e}bora Souza Faffe and Walter Ara{\'u}jo Zin},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={60 5},
Cylindrospermopsin is a cyanobacterial toxin of increasing environmental importance, as it can lead to disease if orally or intravenously absorbed. However, its in vivo lung impairment has not been documented. Thus, we aimed at verifying whether cylindrospermopsin can induce lung injury and establish its putative dependence on the time elapsed since exposure. BALB/c mice were intratracheally injected with either saline (NaCl 0.9%, 50 μL, SAL group, n = 12) or a sublethal dose (70 μg/kg) of semi… CONTINUE READING