Time-course study on doxorubicin-induced nephropathy and cardiomyopathy in male and female LOU/M/Wsl rats: lack of evidence for a causal relationship.

@article{Hoesel1986TimecourseSO,
  title={Time-course study on doxorubicin-induced nephropathy and cardiomyopathy in male and female LOU/M/Wsl rats: lack of evidence for a causal relationship.},
  author={Q. G. Van Hoesel and Peter A. Steerenberg and Jan A. M. A. Dormans and Wim H. de Jong and Dick J de Wildt and Josephus G Vos},
  journal={Journal of the National Cancer Institute},
  year={1986},
  volume={76 2},
  pages={299-307}
}
In a previous study on doxorubicin-induced cardiotoxicity in LOU/M/Wsl rats, severe nephropathy has been observed; therefore, the question was raised whether nephropathy adds to or even might be responsible for doxorubicin-induced cardiomyopathy in rats. For elucidation of this question, the temporal relationship between the onset of doxorubicin-induced cardiomyopathy and nephropathy was studied. In addition, examination was made of whether modifications of the treatment schedule could… CONTINUE READING