Time course of ventricular vulnerability to sustained tachycardia and fibrillation during the early stage of necrosis following acute coronary occlusions in dogs

@article{Guelker1982TimeCO,
  title={Time course of ventricular vulnerability to sustained tachycardia and fibrillation during the early stage of necrosis following acute coronary occlusions in dogs},
  author={Hartmut Guelker and Joachim Thale and K. M. Zurstegge and H. J. Heuer and Fr. Bender},
  journal={Pfl{\"u}gers Archiv},
  year={1982},
  volume={394},
  pages={R7}
}
In ischemic heart tissue the behaviour of heart muscle cells can be followed only with difficulties. Direct access to single ceils is one major advantage of a cell culture model of ischemia. We have shown that Ca ++ tolerant ventricular heart muscle cells can be cultured for days as a population of almost I00 percent of functional, morphological and biochemical intact cells (ATP 6.0, CP 8.7, ADP 0.5, AMP 0.2 ~mol/gww). By this model factors influencing anoxic cell damage can be easily tested, e… CONTINUE READING

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