Time course of the regenerative response in bupivacaine injured orbicularis oculi muscle

@article{McLoon1998TimeCO,
  title={Time course of the regenerative response in bupivacaine injured orbicularis oculi muscle},
  author={Linda K McLoon and Lan Thi Nguyen and Jonathan D. Wirtschafter},
  journal={Cell and Tissue Research},
  year={1998},
  volume={294},
  pages={439-447}
}
Local anesthetics, particularly bupivacaine, are known to be myotoxic to skeletal muscle. Injury is followed by satellite cell mediated regeneration. The eyelid is a common site for the injection of local anesthetics. Due to the complex anatomy of this region and the unique properties of facial musculature compared to limb skeletal muscle, the response of the orbicularis oculi to local injection of bupivacaine was examined to determine the time course of maximum satellite cell activation and… CONTINUE READING

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Adult mammalian extraocular muscles continue to divide

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