Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons.

@article{Wang2002TimecourseOT,
  title={Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons.},
  author={Xueren R. Wang and Juan Carlos G Marviz{\'o}n},
  journal={Brain research},
  year={2002},
  volume={944 1-2},
  pages={239-47}
}
Neurokinin 1 receptor (NK1R) internalization in dorsal horn neurons is important for intracellular signaling in nociception. Since the rates of NK1R internalization and recycling vary substantially, particularly between cultured and native cells, it is imperative to characterize them in dorsal horn neurons. When rat spinal cord slices were incubated at 35 degrees C with 1 microM substance P (SP), NK1Rs in lamina I neurons internalized rapidly following apparent exponential association kinetics… CONTINUE READING

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