Time course of the interaction between tadalafil and nitrates.

  title={Time course of the interaction between tadalafil and nitrates.},
  author={Robert A. Kloner and Adolph M. Hutter and Jeffrey T Emmick and Malcolm I. Mitchell and Jonathan Denne and Graham Jackson},
  journal={Journal of the American College of Cardiology},
  volume={42 10},
OBJECTIVES This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear. Recent guidelines from the American College of Cardiology/American Heart Association recommend that nitrates be withheld for 24 h after taking sildenafil (t(1/2) = 4 h… CONTINUE READING


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