Time course of the in vivo effects of thyroid hormone on cardiac gene expression.

@article{Balkman1992TimeCO,
  title={Time course of the in vivo effects of thyroid hormone on cardiac gene expression.},
  author={Cheryl Balkman and K M Ojamaa and Irwin L Klein},
  journal={Endocrinology},
  year={1992},
  volume={130 4},
  pages={
          2001-6
        }
}
The rate of response to thyroid hormone on cardiac growth, heart rate, and the relative changes in messenger RNA (mRNA) coding for alpha- and beta-myosin heavy chain (MHC), slow sarcoplasmic reticulum calcium-adenosine triphosphatase, and thyroid hormone receptors in ventricular tissue of hypothyroid rats was investigated. Hypothyroid rats had significantly smaller hearts, with slower heart rates and expressed no alpha-MHC mRNA as analyzed by an S1 nuclease protection assay when compared to… CONTINUE READING
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