Time course of the human pulmonary vascular response to 8 hours of isocapnic hypoxia.

@article{Dorrington1997TimeCO,
  title={Time course of the human pulmonary vascular response to 8 hours of isocapnic hypoxia.},
  author={Keith L. Dorrington and C Clar and Jamey D. Young and Marion Jonas and John G Tansley and Peter A. Robbins},
  journal={The American journal of physiology},
  year={1997},
  volume={273 3 Pt 2},
  pages={H1126-34}
}
To examine the hypothesis that the human pulmonary vascular response to hypoxia has a component with a slow time course, we measured pulmonary vascular resistance (PVR) in six healthy adult males during 8 h of isocapnic hypoxia. A balloon-tipped pulmonary artery catheter with thermistor was introduced via a forearm vein and used to derive PVR. The subjects were seated in a chamber in which the oxygen and carbon dioxide concentrations were adjusted to maintain an end-tidal Po2 of 50 Torr and an… CONTINUE READING
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