Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampin

@article{Lee2004TimeCO,
  title={Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampin},
  author={K. H. Lee and J. G. Shin and W. S. Chong and S. Kim and J. Lee and I. Jang and S. G. Shin},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={45},
  pages={287-289}
}
SummaryWe have investigated changes in the pharmacokinetics of prednisolone caused by co-administration or discontinuation of rifampin.Serial IV pharmacokinetic studies of prednisolone (1 mg/kg) in groups of 3 patients over a 1 month period of rifampin co-treatment or after its withdrawal, revealed significant changes in the area under the curve, the total clearance, the non-renal clearance and the half-life. The changes in the pharmacokinetic parameters reached a 1.5 to 2-fold plateau after 2… Expand
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