Time course of the binding of platinum to subfractions of the kidney cytosol in the cisplatin-treated rat.

@article{Mason1986TimeCO,
  title={Time course of the binding of platinum to subfractions of the kidney cytosol in the cisplatin-treated rat.},
  author={R W Mason and S J Hogg and Ivor Ralph Edwards},
  journal={Research communications in chemical pathology and pharmacology},
  year={1986},
  volume={52 1},
  pages={51-8}
}
In male rats treated with cis-dichlorodiammine platinum II (cisplatin, 5 mg/kg, s.c.), the accumulation of Pt in the kidneys occurred in two phases. Total renal Pt content peaked after 15 min and decreased rapidly, then increased to a second peak after 48 hr and thereafter decreased slowly during the next 6 days. Sephadex G-50 chromatography showed that in the kidney cytosol Pt was located in three subfractions; a high molecular weight (HMW) fraction (relative elution volume, Vr = 0.9-1.2), a… CONTINUE READING

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