Time course of the MAPK and PI3-kinase response within 24 h of skeletal muscle overload.

@article{Carlson2001TimeCO,
  title={Time course of the MAPK and PI3-kinase response within 24 h of skeletal muscle overload.},
  author={Christian J. Carlson and Zhong-Kai Fan and Scott E. Gordon and Frank W Booth},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 5},
  pages={2079-87}
}
Knowledge of the molecular mechanisms by which skeletal muscle hypertrophies in response to increased mechanical loading may lead to the discovery of novel treatment strategies for muscle wasting and frailty. To gain insight into potential early signaling mechanisms associated with skeletal muscle hypertrophy, the temporal pattern of mitogen-activated protein kinase (MAPK) phosphorylation and phosphatidylinositol 3-kinase (PI3-kinase) activity during the first 24 h of muscle overload was… CONTINUE READING