Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats.

@article{Koopmans1998TimeCO,
  title={Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats.},
  author={Sietse Jan Koopmans and Lawrence J. Mandarino and R A DeFronzo},
  journal={The American journal of physiology},
  year={1998},
  volume={274 4 Pt 1},
  pages={E642-50}
}
We investigated the time course of insulin action in conscious rats exposed to constant physiological hyperinsulinemia (approximately 100 mU/l) while maintaining euglycemia (approximately 100 mg/dl) for 0, 0.5, 2, 4, 8, or 12 h. [3-3H]glucose was infused to quantitate whole body glucose disposal (rate of disappearance, Rd), glycolysis (generation of 3H2O in plasma), hepatic glucoses production (HGP), and skeletal muscle and liver glycogen synthesis ([3-3H]glucose incorporation into glycogen and… CONTINUE READING