Time course of inhibition of gastric acid secretion by omeprazole and ranitidine in gastric fistula rats.

@article{Seensalu1990TimeCO,
  title={Time course of inhibition of gastric acid secretion by omeprazole and ranitidine in gastric fistula rats.},
  author={Rein Seensalu and Kefyalew Girma and B Romell and Goran Nilsson},
  journal={European journal of pharmacology},
  year={1990},
  volume={180 1},
  pages={145-52}
}
Basal, pentagastrin- and histamine-stimulated acid secretion were measured in gastric fistula rats treated with the H+/K(+)-ATPase inhibitor, omeprazole, and the H2-receptor antagonist, ranitidine. All doses of omeprazole (20, 30, 40, 80, 400 mumol/kg) and ranitidine (125, 187.5, 250, 375 mumol/kg) essentially abolished the basal acid output for various periods of time. Omeprazole, 80 mumol/kg, administered twice daily, reduced the 24-h basal acid secretion more effectively than did 400 mumol… CONTINUE READING