Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids.

@article{Siess1996TimeCO,
  title={Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids.},
  author={Martin Siess and J R Perez Mas and Marie Chantal Canivenc-Lavier and Marc Suschetet},
  journal={Journal of toxicology and environmental health},
  year={1996},
  volume={49 5},
  pages={481-96}
}
Effects of continuous feeding flavonoids (flavone, flavanone, and tangeretin) on drug-metabolizing enzymes in rat liver were investigated to ascertain how long feeding is required to reach maximal induction and to determine whether maximal induction is maintained for a long period of feeding. In the first experiment rats received a diet containing 10 mmol flavonoid/kg dry matter for 4, 8, 16, or 32 d. The second experiment was designed to examine the time course for induction during the first 4… CONTINUE READING