Time course of histomorphological changes in adipose tissue upon acute lipoatrophy.

@article{Murano2013TimeCO,
  title={Time course of histomorphological changes in adipose tissue upon acute lipoatrophy.},
  author={Incoronata Murano and Joseph M Rutkowski and Qiong A. Wang and Y-R Cho and Phillip E Scherer and Saverio Cinti},
  journal={Nutrition, metabolism, and cardiovascular diseases : NMCD},
  year={2013},
  volume={23 8},
  pages={723-31}
}
BACKGROUND AND AIMS Crown-like structures (CLS) are characteristic histopathology features of inflamed adipose tissues in obese mice and humans. In previous work, we suggested that these cells derived from macrophages primarily involved in the reabsorption of dead adipocytes. Here, we used a well-characterized transgenic mouse model in which the death of adipocytes in adult mice is inducible and highly synchronized. In this "FAT ATTAC" model, apoptosis is induced through forced dimerization of… CONTINUE READING