Time course of histological progression in primary sclerosing cholangitis

  title={Time course of histological progression in primary sclerosing cholangitis},
  author={Paul Angulo and Dirk Russell Larson and Terry M. Therneau and Nicholas F. LaRusso and Kenneth P. Batts and Keith D Lindor},
  journal={American Journal of Gastroenterology},
Objective:The aim of this study was to determine the time course over which patients with primary sclerosing cholangitis (PSC) progress through the histological stages of the disease.Methods:One hundred seven patients with PSC who had at least two liver biopsies were identified. The stage information from two consecutive biopsies formed one observation and a continuous time Markov model was used to describe the rate of progression between biopsies.Results:Three hundred seven liver biopsies were… CONTINUE READING