Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.

  title={Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.},
  author={Ruth M Barrientos and Matthew G Frank and Amy M. Hein and Emily A Higgins and Linda R. Watkins and Jerry W. Rudy and Steven F. Maier},
  journal={Brain, behavior, and immunity},
  volume={23 1},
We previously reported that aging F344XBN rats are more vulnerable to disruptions of memory consolidation processes following an injection of Escherichia coli than are young rats. Furthermore, this disruption was specific to hippocampal-dependent memory. In the present study we examined the time course of the proinflammatory cytokine IL-1 beta in young and old rats following a peripheral injection of E. coli. Compared to young rats, aging rats treated with E. coli showed an exaggerated and… CONTINUE READING


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Publications referenced by this paper.
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Endo toxininduced appear ance of immu no re ac tive inter leu kin1 beta in ram i fied microg lia in rat brain : a light and elec tron micro scopic study

  • A. M. Van Dam, J. Bau er, F. Berke nbosch
  • 1995
Highly Influential
3 Excerpts

Aging sen si tizes mice to behav ioral defi cits induced by cen tral HIV - 1 gp 120

  • S. Jang, J. Chen
  • 2008

Decreased lev els of intra the cal inter leu kin 1 recep tor antag o nist in Alz hei mer ’ s dis ease

  • L. Tong, R. Ba lazs, R. Soi ampornkul
  • Cogn . Dis ord .
  • 2008
1 Excerpt

Early - life infec tion leads to altered BDNF and IL - 1 beta mRNA expression in rat hip po cam pus fol low ing learn ing in adult hood

  • S. D. Bilbo, J. C. Bie den kapp, L. R. Wat kins, J. W. Rudy
  • Brain Behav . Im mun .
  • 2008
2 Excerpts

Age - related alter a tions of apo li po pro tein E and inter leu kin1 beta in the aging brain

  • C. Gemma, P. C. Bick ford
  • 2006

Age and neur o in flam ma tion : a lifetime of psy choneu ro im mune con se quences

  • W. S. T. Grif n, L. C. Stan ley, C. Ling, L. White, L. J. Per rot, C. L. White
  • Clin .
  • 2006

Asso ci a tion between dementia and infec tious dis ease : evi dence from a casecon trol study

  • A. Cos sarizza, D. Monti
  • Alz hei mer Dis . As soc . Dis ord .
  • 2005

Exag ger ated neur o in flam ma tion and sick ness behav ior in aged mice fol low ing acti va tion of the periph e ral innate immune

  • R. W. John son
  • FASEB J .
  • 2005

Improve ment of mem ory for con text by inhi bi tion of caspase1 in aged rats

  • J. George, S. Bleas dale
  • Eur . J . Neu ro sci .
  • 2005

Neo na tal infec tioninduced mem ory impair ment after lipo poly sac charide in adult hood is pre vented via caspase1 inhi bi tion

  • T. V. P. Bliss, T. Lomo
  • 2005

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