Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.

@article{Barrientos2009TimeCO,
  title={Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.},
  author={Ruth M Barrientos and Matthew G Frank and Amy M. Hein and Emily A Higgins and Linda R. Watkins and Jerry W. Rudy and Steven F. Maier},
  journal={Brain, behavior, and immunity},
  year={2009},
  volume={23 1},
  pages={46-54}
}
We previously reported that aging F344XBN rats are more vulnerable to disruptions of memory consolidation processes following an injection of Escherichia coli than are young rats. Furthermore, this disruption was specific to hippocampal-dependent memory. In the present study we examined the time course of the proinflammatory cytokine IL-1 beta in young and old rats following a peripheral injection of E. coli. Compared to young rats, aging rats treated with E. coli showed an exaggerated and… CONTINUE READING

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