Time course of exchanges between red cells and extracellular fluid during CO2 uptake.

@article{Forster1975TimeCO,
  title={Time course of exchanges between red cells and extracellular fluid during CO2 uptake.},
  author={Robert E. Forster and Edward D Crandall},
  journal={Journal of applied physiology},
  year={1975},
  volume={38 4},
  pages={710-8}
}
A stopped-flow rapid-reaction apparatus was used to follow the time course of extracellular pH in a human red cell suspension following a sudden increase in PCO2. The extracellular pH change was slow (t1/2 similar to 3.5 s) considering the presence of carbonic anhydrase in the cells. When carbonic anhydrase was added to the extracellular fluid, the half-time was reduced to less than 20 ms. The explanation for these phenomena is that the equilibration of H+ across the red cell membrane is rate… CONTINUE READING

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