Time course of desflurane-induced preconditioning in rabbits.

  title={Time course of desflurane-induced preconditioning in rabbits.},
  author={Thorsten M. Smul and Andreas Redel and Jan Stumpner and Markus Lange and Christopher A Lotz and Norbert Roewer and Franz Kehl},
  journal={Journal of cardiothoracic and vascular anesthesia},
  volume={24 1},
OBJECTIVES The authors tested the hypothesis that volatile anesthetic-induced preconditioning (APC) follows a similar time pattern as that described for ischemic preconditioning and that delayed APC is mediated by nitric oxide. DESIGN A prospective randomized vehicle-controlled study. SETTING A university research laboratory. SUBJECTS New Zealand white rabbits (n = 75). METHODS Rabbits were instrumented for the measurement of systemic hemodynamics and subjected to a 30-minute coronary… CONTINUE READING

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