Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel®) in patients with schizophrenia

Abstract

Quetiapine (Seroquel) is a novel antipsychotic with an atypical profile in animal models and a relatively short plasma half-life of 2.5–5 h. In the present study, we used PET to compare the time course of blockade of dopamine D2 and serotonin 5HT2 receptors of quetiapine using C11-raclopride and C11-N-methyl-spiperone as ligands, parallel to monitoring… (More)
DOI: 10.1007/s002130050492

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Cite this paper

@article{Gefvert1998TimeCO, title={Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel®) in patients with schizophrenia}, author={Ola Gefvert and M Andresen Bergstr{\"o}m and Bo L{\aa}ngstr{\"o}m and Tomas Lundberg and Linda Lindstr{\"o}m and Ronald Yates}, journal={Psychopharmacology}, year={1998}, volume={135}, pages={119-126} }