Time course of bleomycin-induced lung fibrosis.

  title={Time course of bleomycin-induced lung fibrosis.},
  author={Gabriel Izbicki and Michael J. Segel and Thomas G. Christensen and Michael W. Conner and Raphael Breuer},
  journal={International journal of experimental pathology},
  volume={83 3},
Intratracheal instillation (IT) of bleomycin is a widely used experimental model for lung fibrosis. In this study we describe the time-course of bleomycin-induced lung fibrosis in mice using computer-assisted morphometry. C57Bl/6J mice were treated with a single IT dose of bleomycin or control saline. Animals were killed 3, 6, 14 and 21 days post-IT. Lung… CONTINUE READING