Time course of acute phase in mouse spinal cord injury monitored by ex vivo quantitative MRI.

@article{Gaviria2006TimeCO,
  title={Time course of acute phase in mouse spinal cord injury monitored by ex vivo quantitative MRI.},
  author={Manuel Gaviria and Jean-Marie Bonny and Henri Haton and Beatrix Jean and Marisa Teigell and Jean-Pierre Renou and Alain Privat},
  journal={Neurobiology of disease},
  year={2006},
  volume={22 3},
  pages={694-701}
}
During the acute phase of spinal cord injury (SCI), major alterations of white and grey matter are a key issue, which determine the neurological outcome. The present study with ex vivo quantitative high-field magnetic resonance microimaging (MRI) was intended in order to identify sensitive parameters of tissue disruption in a well-controlled mouse model of ischemic SCI. MR imaging evidenced changes as early as the second hour after the lesion in the dorsal horns, which appear swollen. After 4 h… CONTINUE READING

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