Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen.

@article{Tegeder2002TimeCO,
  title={Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen.},
  author={Irmgard Tegeder and Lutz Br{\"a}utigam and Maurizio Podda and Silke Meier and Roland Kaufmann and Gerd 7 Geisslinger and Marcella Grundmann-Kollmann},
  journal={Clinical pharmacology and therapeutics},
  year={2002},
  volume={71 3},
  pages={153-61}
}
BACKGROUND The combination of 8-methoxypsoralen with ultraviolet A exposure (PUVA therapy) is a standard treatment for a variety of dermatoses. The following three variants have been described: oral, bath, or cream PUVA. To achieve optimal therapeutic effects, ultraviolet A irradiation should be performed at the time of maximum photosensitivity, that is, at the time of maximum 8-methoxypsoralen tissue concentrations. METHODS To further specify this point of time, we assessed the concentration… CONTINUE READING

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