Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury.

@article{Mitsumoto2017TimecourseMR,
  title={Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury.},
  author={Koji Mitsumoto and Rina Watanabe and Katsuki Nakao and Hisaki Yonenaka and Takao Hashimoto and Norihisa Kato and Thanutchaporn Kumrungsee and Noriyuki Yanaka},
  journal={Life sciences},
  year={2017},
  volume={184},
  pages={103-111}
}
AIMS Choline-deficient diet is extensively used as a model of nonalcoholic fatty liver disease (NAFLD). In this study, we explored genes in the liver for which the expression changed in response to the choline-deficient (CD) diet. MAIN METHODS Male CD-1 mice were divided into two groups and fed a CD diet with or without 0.2% choline bitartrate for one or three weeks. Hepatic levels of choline metabolites were analyzed by using liquid chromatography mass spectrometry and hepatic gene… CONTINUE READING