Time course gene expression data in colon of mice after exposure to food-grade E171

  title={Time course gene expression data in colon of mice after exposure to food-grade E171},
  author={H{\'e}lo{\"i}se Proquin and Marlon J. A. Jetten and Marloes C. M. Jonkhout and Luis Guillermo Gardu{\~n}o-Balderas and Jacob J. Bried{\'e} and Theo M. de Kok and Yolanda Irasema Chirino and Henk van Loveren},
  journal={Data in Brief},
  pages={531 - 600}
We investigated gene expression responses in BALB/c mice exposed by gavage to 5 mg/kg bw/day of E171 for 2, 7, 14 and 21 days. Food additive E171 (titanium dioxide) has been shown to induce oxidative stress and DNA damage in vitro as well as facilitating growth of colorectal tumours in vivo. Full genome expression changes of the colon of mice were investigated by using Agilent SurePrint G3 mouse Gene exp 60kv2 microarrays slides. The data presented in this DiB include all differentially… 
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EFSA concludes that the ANSES opinion published in April 2019 does not identify any major new findings that would overrule the conclusions made in the previous two scientific opinions on the safety of titanium dioxide (E 171) as a food additive issued by the EFSA ANS Panel in 2016 and 2018.


Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171).
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The results may offer a mechanistic framework for the enhanced tumour growth after ingestion of E171 in BALB/c mice.
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